Complex Formation between Bacitracin Peptides and Isoprenyl Pyrophosphates
نویسندگان
چکیده
منابع مشابه
Complex formation between bacitracin peptides and isoprenyl pyrophosphates. The specificity of lipid-peptide interactions.
The technique used previously to observe complex formation between bacitracin, Mg++, and Ca5-isoprenyl pyrophosphate has been employed to measure association constants. The constant for the bacitracin A, Mg++, C55-isoprenyl pyrophosphate complex was lo6 M-I. The binding constants for other bacitracin peptides were lower and correlated with their antibiotic activities. &farnesyl pyrophosphate al...
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The inhibition by bacitracin of the enzymatic dephosphorylation of C(55)-isoprenyl pyrophosphate is abolished by the addition of chelating agents. If, however, the chelating agent is added after a preincubation of bacitracin with a divalent cation and the lipid substrate, then its addition has little effect, indicating that bacitracin, metal ion, and C(55)-isoprenyl pyrophosphate form a complex...
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Bacitracin was tritiated by the Wilzbach technique and purified by carboxymethylcellulose chromatography. Binding studies between [3H]bacitracin and Micrococcus lysodeikticus cells and protoplasts indicated that the cells or protoplasts were saturated at 2 X lo5 molecules per cell. This value correlates well with the number of CS5-isoprenyl pyrophosphate molecules found in the membrane and adds...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43823-4